Category: Huntington’s Disease

Introduction of Huntingtons disease Huntingtons disease (HD) is a severe neurodegenerative disorder that is inherited in an autosomal dominant manner. HD progresses in mid-life showing motor and cognitive function impairments, and psychiatric deficiencies. It is caused by a mutation of the Huntingtin gene creating a CAG-elongation at the amino-terminus of the Huntingtin protein (HTT)1. Having…

Huntington’s disease is an inherited brain disorder that is caused when specific cells in the brain die. This leads to loss of cognitive function, loss of walking, eating and swallowing and eventually death. Symptoms typically start between 30-50-year old Huntington’s disease is extremely rare and affects one in every 10,000 people. Huntingtons disease is caused…

Rationale Congenital diseases are disorders that are present before or at birth. (spine-health, 2019) Huntingtons disease is a hereditary disease that is more common in European descent. (ghr, 2019) It will usually affect hosts at the ages between 30-40, but there are cases of juvenile Huntingtons disease and late-onset. ‘Huntingtons disease causes the breakdown of…

Human Genetics and Genomics- Nonallele-specific Silencing of Mutant and Wild-type Huntingtin Demonstrates Therapeutic Efficacy in Huntingtons Disease Mice Huntington`s Disease (HD) is an autosomal dominant neurodegenerative disease affecting 4-to-7 per 100,000 individuals. It is classed as a trinucleotide repeat disorder (Marcy et al, 1993) due to the fact that it results from an expanded CAG…

Narrative In my early 40s I began to have more difficulty concentrating, and I remember feeling unusually forgetful. For a while, I ignored these symptoms until I started to uncontrollably twitch and make fidgety motions. When the chorea started, it was clear to my doctor that I was dealing with something more than just forgetfulness.…

There are many diseases out in the world that are affecting peoples lives in different ways. They can either be an infectious or a non-infectious disease. A non- infectious disease would be Huntingtons disease which is inherited. It causes a severe breakdown of nerve cells of the brain. The parts of the brain that get…